Tissue Dissociation Market

SKU: DMBT4049 | Last Updated On: Nov 30 2022 | Available Formats

> Tissue Dissociation Market Expected to reach a high CAGR 18.9% By 2029:

Tissue Dissociation Market is segmented By Tissue type (Epithelial Tissue, Connective Tissue), By Dissociation Enzyme (Collagenase, Trypsin, Elastase, Hyaluronidase, Papain, Chymotrypsin, Trypsin Inhibitor, Animal Origin Free (AOF) Enzymes, Others), By End-user (Research Institutes, Pharmaceutical Companies, Biotechnology Companies, Diagnostic Laboratories), By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2022-2029

Tissue Dissociation Market is predicted to reach at a high CAGR 18.9% during the forecast period (2022-2029).

Tissue dissociation is a cell separation process that separates the human and animal tissues. It is performed with the help of isolation enzymes to maximize the outcome of functionally viable, dissociated cells.

Tissue Dissociation Market Growth Dynamics

Increasing focus on developing monoclonal antibodies and customization of the drug manufacturing process is driving market growth.

N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies. It plays a key role in a myriad of drug properties associated with biological function. In addition, the glycosylation profile of recombinant monoclonal antibodies is determined by the order of cell culture inputs that are carefully controlled to engineer the desired glycan distribution. The method is shown to be linear, accurate, specific, and precise for an IgG1 and IgG4 mAb supporting relative quantitation of mannose-5 in the range 0.8–11.0% and 1.0–6.2%, respectively. The method can also be applied at several stages of the production process, from cell culture harvest to drug substance/drug product and is responsive to routine GMP batch testing in a quality control laboratory. Testing upstream during cell culture rather than for product release allows for a more advanced product quality assessment as the glycosylation profile remains unchanged during downstream purification.

Limitations of the Hyaluronidase enzyme are likely to hamper the market growth

Adoptive T cell therapies, including chimeric antigen receptor T cells, have produced strong responses in patients with hematological malignancies. However, the efficacy of CAR-T cells in solid tumor patients remains uncertain, and the microenvironment of solid tumors is accepted to be a major obstacle that causes the lack of efficacy. Since low infiltration efficiency is a limitation of T cell therapy against solid cancers, and PH20 may enhance CAR-T cells' infiltrating capacity, the combination of PH20 with CAR-T cell therapy is of translational potential and remains to be explored.

COVID-19 Impact Analysis

The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. A mix of established pharmaceutical and biopharmaceutical companies and small startups has moved forward to advance treatments and vaccines that target the infection caused by the novel coronavirus. The COVID-19 outbreak has significantly impacted the availability of hospital resources worldwide. It has been managed by dramatically decreasing inpatient and outpatient services for other diseases and performing infection prevention and control measures. The number of cancer screening and diagnostic procedures declined precipitously, with countries worldwide being affected by the pandemic.

Tissue Dissociation Market Scope



Market CAGR


Segments Covered

By Tissue type, By Dissociation Enzyme, By End-user, and By Region

Report Insights Covered

Competitive Landscape Analysis, Company Profile Analysis, Market Size, Share, Growth, Demand, Recent Developments, Mergers and acquisitions, New Product Launches, Growth Strategies, Revenue Analysis, and Other key insights.

Fastest Growing Region

Asia Pacific

Largest Market Share 

North America

Tissue Dissociation Market Segment Analysis

Collagenase segment is expected to hold the largest market share in this market segment.

The collagenase segment is estimated for the largest market share in 2020, according to the frontiers, published on 22 July 2021, The usage of enzymes for tissue dissociation is a common procedure that allows the retainment of cell viability and integrity by uniting proper tissue digestion. The most widely used enzyme is collagenase; however, it is used with other enzymes as collagenase belongs to the class of endopeptidases and digests collagen in the region of the triple helix. Moreover, collagen is the leading component in connective tissue; thus, collagenase is useful when isolating epithelial, endothelial, or adrenal tissue, and it is applied to isolate adipocytes, hepatocytes, cardiomyocytes, and the treatment of mammary or other soft tissues. The procedure of cell isolation with collagenase and hyaluronidase is also successful in breast cancer. Therefore, it is possible to acquire a higher cell yield.

Tissue Dissociation Market Geographical Analysis

North America region holds the largest market share in the global tissue dissociation market.

North America accounted for largest revenue share in 2020 and expected to dominate over the forecast period, owing to high focus on biotechnology-related research; the best research institutes, increasing demand for biopharmaceutical products in the region are expected to boost the market in the forecast period. For instance, according to the frontiers, the biopharmaceutical industry is rapidly developing in the pharmaceutical industry, with enormous opportunities and implications for healthcare. Moreover, opportunities in biopharmaceuticals have been increasing over the past decade due to the great effectiveness and the safety of these drugs. In addition, biopharmaceuticals offer several benefits, such as highly effective and potent action, fewer side effects, and the potential to cure diseases rather than merely treat the symptoms, significantly increasing the demand for biopharmaceutical products.

Tissue Dissociation Market Competitive Landscape

The tissue dissociation market is vast with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Miltenyi Biotec, Worthington Biochemical, Sigma-Aldrich, F. Hoffmann-La Roche, Becton Dickinson Biosciences, Thermo Fisher Scientific, StemCell Technologies, Inc., VitaCyte and Merck KGaA. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the tissue dissociation market globally.

Tissue Dissociation Market Key Companies to Watch

Thermo Fisher Scientific:


Thermo Fisher Scientific is an American provisioner of scientific instrumentation, reagents and consumables, and software services. Based in Waltham, Massachusetts, Thermo Fisher was formed by combining Thermo Electron and Fisher Scientific in 2006. Thermo Fisher has acquired other reagent, consumable, instrumentation, and service providers, including Life Technologies Corporation (2013), Alfa Aesar (2015), Affymetrix (2016), FEI Company (2017).

Product Portfolio:

Thermo Fisher Scientific has continuously set new standards for manufacturing products, including 101 BIO TISSUE DISSOCIATION ISOLAT DIR, MilliporeSigma ProteoExtract Tissue Dissociation Buffer Kit and others.

Frequently Asked Questions

What is the Projected CAGR value of the Tissue Dissociation Market?

Tissue Dissociation Market is expected to grow at a CAGR of 18.9% during the forecasting period 2022-2029.

Which region controlled the global market during 2022-2029?

North America region Controls the Tissue Dissociation Market during 2022-2029

Which is the fastest growing region in the Tissue Dissociation Market?

Among all regions, Asia Pacific is the fastest growing market share during the forecast period 

Trending Topics

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Monoclonal Antibody Therapeutics Market

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