Interleukin Inhibitors Market Size
The Global Interleukin Inhibitors Market reached US$ 49.56 billion in 2024 and is expected to reach US$ 116.42 billion by 2032, growing at a CAGR of 8.5% during the forecast period 2025-2032.
Pipeline Drugs
Interleukin inhibitors are the drugs that suppress the activity of interleukins, which are the major mediators in the inflammatory pathway and regulators of the body’s immune system. Interleukins were found to play a crucial role in the pathophysiology of various chronic diseases such as psoriasis, eczema, inflammatory bowel disease, rheumatoid arthritis, asthma, cardiovascular conditions, infectious diseases, etc. Suppressing or modifying their activity is an essential mechanism in the treatment of aforementioned chronic diseases. Interleukin inhibitors act selectively by targeting receptors, proteins specific to the interleukin. This selective inhibition is essential to block a specific interleukin that is designated to play a role in particular disease pathology. Currently, there are several interleukin inhibitors targeting various interleukins such as IL-1, IL-2, IL-6, IL-12, IL-17, IL23, IL-36, etc.
The market for these inhibitors is expected to be driven by the rising prevalence of chronic inflammatory diseases, advancements in understanding disease pathophysiology, and increased focus on research and development activities to develop specific interleukin inhibitors that target the suspected interleukin.
Executive Summary
For more details on this report – Request for Sample
Market Dynamics: Drivers & Restraints
The Rising Prevalence of Chronic Inflammatory Conditions
The rising prevalence and incidence of chronic inflammatory conditions is a significant driver for the interleukin inhibitors market growth. These drugs are aimed at inhibiting the interleukins that play a crucial role in chronic inflammatory disease pathophysiology. The major indications for interleukin inhibitors are psoriasis, rheumatoid arthritis, asthma, inflammatory bowel disease, eczema, etc. As the prevalence of these conditions rises, the demand for advanced therapies such as interleukin inhibitors is also expected to rise, propelling the market growth positively in the forecasted period.
For instance, as per DataM intelligence prevalence forecasts, the global population with IBD is expected to reach 5.43 million in 2030 from 4.93 million in 2024. The incidence rate is also expected to rise from 363k cases in 2024 to 386k cases in 2030.
High Cost of Interleukin Inhibitors may restrain the market growth.
Interleukin inhibitors are revolutionizing the treatment of several chronic inflammatory conditions, however, their higher cost may reduce their adoption rate. This is especially seen in low and middle-income countries, and patients who lack reimbursement. For instance, Dupixent (dupilumab) which is the top-selling interleukin inhibitor due to its high prices, may not be affordable for patients who lack insurance coverage. Patients who don’t have insurance coverage have to pay more than the list price which is US$3,803.20 per 2 injections.
Market Segment Analysis
The global interleukin inhibitors market is segmented based on target, indication, distribution channel, and region.
Psoriasis in the indication segment is expected to dominate the market.
Psoriasis is a chronic autoimmune condition affecting the skin of a patient. The condition results from hyperactivity of immune cells, especially the interleukins, and is characterized by epidermal hyperplasia and infiltration of immune cells into the skin layers. The IL-23/IL-17 axis is the major driver for the disease whose activation results in a cascade of events such as the release of cytokines, inflammatory mediators, and then activation of keratinocytes. This activation may lead to excessive inflammation and ultimately the condition called psoriasis. There are different types of psoriasis, of which plaque psoriasis is the most common one characterized by red patchy skin and white scales. Moreover, psoriasis patients are at higher risk of developing other inflammatory conditions such as psoriatic arthritis, severe cardiovascular events, etc.
Although the currently approved interleukin inhibitors are indicated in various chronic inflammatory conditions, most of them were first approved for the treatment of one or the other kind of psoriasis and its related complications. However, the prevalence of psoriasis is also high, and as per the National Psoriasis Foundation, there were nearly 125 million affected with psoriasis worldwide.
Market Geographical Share
North America is expected to hold a significant share of the interleukin inhibitors market.
North America currently holds a significant market share in the interleukin inhibitors market due to various factors including, higher demand for novel therapies, major revenue generated by market players, and increasing prevalence of chronic inflammatory conditions. Any emerging drug is expected to first get launched in the U.S. market due to higher demand, and all the interleukin inhibitors in the current market were first launched in the U.S., providing first access to the patients in the country. Due to higher per-capita income and spending on healthcare, the interleukin inhibitors are sold at higher prices in the North America market as compared to other nations. Due to this, manufacturers generate a majority of their revenue from the region.
For instance, below are the top 10 selling interleukin inhibitors and their revenue share from the U.S. market.
Competitive Landscape
The major global players in the interleukin inhibitors market are Sanofi, Regeneron Pharmaceuticals, Inc., Novartis AG, Eli Lilly and Company, GSK plc., Johnson & Johnson Services, Inc., AstraZeneca., AbbVie., F. Hoffmann-La Roche Ltd, Sun Pharmaceutical Industries, Inc., Ortho Dermatologics’ affiliated entities., Sobi, Inc., UCB, Inc., Teva Pharmaceutical Industries Ltd., LEO Pharma Inc., Kiniksa Pharmaceuticals., Boehringer Ingelheim International GmbH., and Galderma Laboratories, L.P. among others.
Emerging Players
The emerging players in the interleukin inhibitors market include AnaptysBio, Inc., Huabo Biopharm (Shanghai) Co., Ltd., CSL, and DICE Therapeutics among others.
Key Developments
- In September 2024, the U.S. Food and Drug Administration (FDA) approved BIMZELX (bimekizumab-bkzx) for the treatment of adult patients with active psoriatic arthritis and active non-radiographic axial spondyloarthritis. Bimzelx developed by UCB, is an interleukin 17A & 17F inhibitor that is available in s.c. Injection is administered every four weeks.
- In September 2024, the U.S. Food and Drug Administration (FDA) approved EBGLYSS (lebrikizumab-lbkz) for the treatment of adult and child patients above 12 years of age having moderate to severe atopic dermatitis. Ebglyss developed by Eli Lilly and Company is an IL-13 inhibitor available in i.v. formulation.
| Metrics | Details | |
| CAGR | 8.5% | |
| Market Size Available for Years | 2022-2032 | |
| Estimation Forecast Period | 2025-2032 | |
| Revenue Units | Value (US$ Mn) | |
| Segments Covered | Target | Interleukin-1, Interleukin-2, Interleukin-6, Interleukin-12, Interleukin-17, Interleukin-23, and Others |
| Indication | Psoriasis, Atopic Dermatitis, Arthritis, Asthma, Inflammatory Bowel Disease (IBD), and Others | |
| Distribution Channel | Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies | |
| Regions Covered | North America, Europe, Asia-Pacific, South America, and Middle East & Africa | |
Why Purchase the Report?
- Pipeline & Innovations: Reviews ongoing clinical trials, and product pipelines, and forecasts upcoming pharmaceutical advancements.
- Target Performance & Market Positioning: Analyzes product performance, market positioning, and growth potential to optimize strategies.
- Real-World Evidence: Integrates patient feedback and data into product development for improved outcomes.
- Physician Preferences & Health System Impact: Examines healthcare provider behaviors and the impact of health system mergers on adoption strategies.
- Market Updates & Industry Changes: Covers recent regulatory changes, new policies, and emerging technologies.
- Competitive Strategies: Analyzes competitor strategies, market share, and emerging players.
- Pricing & Market Access: Reviews pricing models, reimbursement trends, and market access strategies.
- Market Entry & Expansion: Identifies optimal strategies for entering new markets and partnerships.
- Regional Growth & Investment: Highlights high-growth regions and investment opportunities.
- Supply Chain Optimization: Assesses supply chain risks and distribution strategies for efficient Target delivery.
- Sustainability & Regulatory Impact: Focuses on eco-friendly practices and evolving regulations in healthcare.
- Post-market Surveillance: Uses post-market data to enhance product safety and access.
- Pharmacoeconomics & Value-Based Pricing: Analyzes the shift to value-based pricing and data-driven decision-making in R&D.
The global interleukin inhibitors market report would provide approximately 86 tables, 69 figures, and 265 pages.
Target Audience 2025
- Manufacturers: Pharmaceutical, Biotech Companies, Contract Manufacturers, Distributors, Hospitals.
- Regulatory & Policy: Compliance Officers, Government, Health Economists, Market Access Specialists.
- Technology & Innovation: R&D Professionals, Clinical Trial Managers, Pharmacovigilance Experts.
- Investors: Healthcare Investors, Venture Fund Investors, Pharma Marketing & Sales.
- Consulting & Advisory: Healthcare Consultants, Industry Associations, Analysts.
- Supply Chain: Distribution and Supply Chain Managers.
- Consumers & Advocacy: Patients, Advocacy Groups, Insurance Companies.
- Academic & Research: Academic Institutions.
