Allogeneic Stem Cells Market Size Share and Industry Outlook to 2028

SKU: DMPH4054 | Last Updated On: Sep 30 2021 | No. of Pages: 180 | Available Formats

> Global Allogeneic Stem Cells Market Expected to reach a high CAGR of 12.04% By 2028: DataM Intelligence

Global Allogeneic Stem Cells Market is segmented By Product (Progesterone Oral, Progesterone Injection, Progesterone Suspended/Gel, Others), By Application (Hospital, Clinic, Pharmacies, and Drug Stores)By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2021-2028

 

Market Overview

The "Global Allogeneic Stem Cells Market" is predicted to reach at a high CAGR of 12.04% during the forecast period (2021-2028) 

Allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace diseased or damaged bone marrow.

Source: DataM Intelligence Analysis (2020)

Market Dynamics

The increasing prevalence of Ischemic heart disease is expected to drive the market's growth.

According to the National Center for Biotechnology Information, Ischemic heart disease, also called coronary heart disease (CHD), is a heart problem caused by narrowed heart (coronary) arteries that supply blood to the heart muscle. Although the narrowing is caused by a blood clot or by constriction of the blood vessel, it is often caused by the buildup of plaque, called atherosclerosis. IHD affects around 126 million individuals (1,655 per 100,000), approximately 1.72% of the world's population.

Moreover, nine million deaths were caused by IHD globally. Men were more usually affected than women, and incidence typically started in the fourth decade and increased with age. The study estimated that the current prevalence rate of 1,655 per 100,000 population is expected to exceed 1,845 by 2030. Stem cell transplantation has become a viable approach for the treatment of IHD in recent times. Additionally, it is generally recognized that preclinical cell-based therapy is effective and has yielded encouraging results, which involves preventing or reducing myocardial cell death, inhibiting scar formation, promoting angiogenesis, and improving cardiac function. Thus, the allogeneic stem cells market is expected to propel in the forecast period from the above statements.

Side effects of allogeneic stem cell transplant are expected to hamper the market's growth.

According to the American Cancer Society, Many of the problems after the transplant come from having the bone marrow cleared out by medicines or radiation just before the transplant. Others may be side effects of the conditioning treatments themselves. For instance, GVHD reactions are very common and can range from barely noticeable to life-threatening. Acute GVHD starts after the transplant and lasts a short time, and chronic GVHD starts later and lasts a long time. Some person could have one, both, or neither type of GVHD.

Moreover, About one-third to one-half of allogeneic transplant recipients will develop acute GVHD. It's less common in younger patients and those with closer HLA matches between donor and the patient. The first signs are normally a rash, burning, and redness on the palms and soles. It can spread over the entire body. Therefore, other symptoms can include Nausea, Vomiting, Stomach cramps, Diarrhea (watery and sometimes bloody), Loss of appetite and others. Thus, from the above statements, the market is expected to ger hampered in the forecast period.

COVID-19 Impact Analysis

The COVID-19 pandemic has affected the healthcare systems and has a notable impact on the market. Widespread community transmission in the United States triggered a nationwide shutdown, raising major challenges for administering hematopoietic stem cell transplant (HSCT) and chimeric antigen receptor (CAR)-T cell therapies, leading many centers to delay or cancel operations. Moreover, abrupt shutdown presented major challenges in coordinating and delivering hematopoietic stem cell transplant (HSCT) and immune cell-based therapies, including chimeric antigen receptor T cells (CAR-T). Many other transplant programs are forced to reduce transplant volume, if not stop completely. Guidance from the European Society for Blood and Marrow Transplantation included a deferral of nonurgent transplants when possible. The ban on international air travel and interruption of domestic routes disrupted the reliable transport of donor products. Restrictions on travel rendered evaluation difficult for prospective donors out of concern for travel-related COVID-19 exposures. Thus, the COVID-19 pandemic has affected the market. However, the situation is expected to improve gradually in the forecast period.

Market Segment Analysis

Progesterone Suspended/Gel segment is expected to hold the largest market share in this market segment.

The progesterone suspended/gel segment is estimated for the largest market share in 2020. The segment growth benefits to the increasing prevalence of ocular graft-versus-host disease are expected to boost the market in the forecast period. For instance, according to the American Society for Transplantation and Cellular Therapy, Ocular graft-versus-host disease (GVHD) is a complexity of allogeneic hematopoietic stem cell transplantation (HSCT), where an immunologic response by donor cells against host tissues happens due to conflict between the recipient and donor cells. To date, there are no Food and Drug Administration-approved treatments for ocular chronic graft-versus-host disease (oGVHD), and current therapeutic options are limited. Forehead application of 1% progesterone gel provides corneal antinociception in preclinical models, suggesting it may alleviate ocular irritations.

Moreover, a study was conducted to evaluate the efficacy and safety of 1% progesterone gel in treating moderate to severe symptomatic oGVHD. Patients with oGVHD following allogeneic stem cell transplantation are enlisted in this single-center, sponsor-initiated, prospective exploratory randomized double-masked placebo-controlled phase II clinical trial. In addition, the inclusion criteria involved a National Institutes of Health consent score of ≥2, moderate to severe ocular discomfort level, and receipt of a stable immunosuppression regimen. Therefore, no difference is noted in superior cornea staining. There were no severe adverse events in the progesterone group, and forehead application of 1% progesterone gel significantly improved ocular signs and symptoms within ten weeks. It appears to be a safe and effective new therapy for oGVHD and a novel mechanism for neuroaxis drug delivery. Thus, the market segment is expected to hold the largest market share in the forecast period from the above statements.

Source: DataM Intelligence Analysis (2020)

Geographical Analysis

North America region holds the largest market share in the global allogeneic stem cells market.

North America dominated the market in 2020. The region's growth is attributed to the increase in economic growth and the increase in the prevalence of target chronic diseases, rise in the investment scenario, high adoption of advanced technology is expected to boost the market in the forecast period. For instance, according to BioMed Central, published on 25 November 2020, allogeneic hematopoietic stem cell transplantation after CAR T-cell therapy has appeared as a promising strategy to prolong leukemia-free survival (LFS). Although anti-CD19 chimeric antigen receptor (CAR) T-cell therapy shows much effectiveness in patients with relapsed/ refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), it fails to develop long-term leukemia-free survival (LFS).

Moreover, recent clinical data show that patients with complex karyotypes, adverse genes, and high pre-infusion minimal residual disease (MRD) by flow cytometry in the bone marrow had a high chance of relapse after CAR T-cell therapy. But patients having these risk factors, consolidative allo-HSCT after CAR T-cell therapy may prolong LFS. However, advances in chimeric antigen receptor (CAR) T-cell therapy have enhanced the treatment of r/r B-ALL, as the first FDA-approved CD19-targeted CAR T-cell therapy, Tisagenlecleucel, has recently been proved as the standard of care for r/r B-ALL patients aged under 26 as per the NCCN Guidelines. Thus, the North American region is expected to hold the largest market share in the forecast period from the above statements.

Source: DataM Intelligence Analysis (2020)

Competitive Landscape

The allogeneic stem cells market is vast with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Biosolution Co. Ltd., Cynata Therapeutics Ltd., JCR Pharmaceuticals Co. Ltd., Lineage Cell Therapeutics Inc., MEDIPOST Co. Ltd., MiMedx Group Inc., Osiris Therapeutics Inc., Stempeutics Research Pvt. Ltd. and Takeda Pharmaceutical Co. Ltd. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the allogeneic stem cells market globally.

Allogeneic Stem Cells Market Key Companies to Watch

Takeda Pharmaceuticals:

Overview:

Takeda Pharmaceuticals is a patient-focused, values-based, R&D-driven global biopharmaceutical company committed to bringing better health and a brighter future to people worldwide. The company discovers and develops innovative biological medicines and makes them accessible to patients throughout the world. Moreover, the company's R&D efforts are focused on four therapeutic areas: Oncology, Rare Diseases, Neuroscience, and Gastroenterology (GI). The company also makes targeted R&D investments in Plasma-Derived Therapies and Vaccines, and in 2021, Takeda announced the approval of Moderna's COVID-19 vaccine in Japan.

Product Portfolio:

Takeda Pharmaceuticals has continuously set new standards for manufacturing Alofisel® (darvadstrocel).

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Target Audience

  • Service Providers/ Buyers
  • Industry Investors/Investment Bankers
  • Education & Research Institutes
  • Research Professionals
  • Emerging Companies
  • Manufacturers

Market Segmentation

Global Allogeneic Stem Cells Market – By Product

  • Progesterone Oral
  • Progesterone Injection
  • Progesterone Suspended/Gel
  • Others

Global Allogeneic Stem Cells Market – By Application

  • Hospital
  • Clinic
  • Pharmacies and Drug Stores

Global Allogeneic Stem Cells Market - By Region

  • North America
  • South America
  • Europe
  • Asia Pacific
  • Middle East & Africa

Table of Contents

  1. Global Allogeneic Stem Cells Market Methodology and Scope

    1. Research Methodology
    2. Research Objective and Scope of the Report
  2. Global Allogeneic Stem Cells Market – Market Definition and Overview

  3. Global Allogeneic Stem Cells Market – Executive Summary

    1. Market Snippet by Product
    2. Market Snippet by Application
    3. Market Snippet by Region
  4. Global Allogeneic Stem Cells Market – Market Dynamics

    1. Market Impacting Factors
      1. Drivers
        1. The increasing prevalence of Ischemic heart disease is expected to drive the market's growth.
        2. The rise in the investment by the pharmaceutical and biopharmaceutical companies for stem cell research is expected to drive the market's growth.
      2. Restraints:
        1. Side effects of allogeneic stem cell transplant are expected to hamper the market's growth.
      3. Opportunity
      4. Impact Analysis
  5. Global Allogeneic Stem Cells Market – Industry Analysis

    1. Porter's Five Forces Analysis
    2. Epidemiology Analysis
    3. Supply Chain Analysis
    4. Pricing Analysis
    5. Regulatory Analysis
    6. Reimbursement Analysis
    7. Unmet Needs
  6. Global Allogeneic Stem Cells Market – COVID-19 Analysis

    1. Analysis of Covid-19 on the Market
      1. Before COVID-19 Market Scenario
      2. Present COVID-19 Market Scenario
      3. After COVID-19 or Future Scenario
    2. Pricing Dynamics Amid Covid-19
    3. Demand-Supply Spectrum
    4. Government Initiatives Related to the Market During Pandemic
    5. Manufacturers Strategic Initiatives
    6. Conclusion 
  7. Global Allogeneic Stem Cells Market – By Product

    1. Introduction
      1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
      2. Market Attractiveness Index, By Product Segment
    2. Progesterone Oral*
      1. Introduction
      2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
    3. Progesterone Injection
    4. Progesterone Suspended/Gel
    5. Others
  8. Global Allogeneic Stem Cells Market – By Application

    1. Introduction
      1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
      2. Market Attractiveness Index, By Application Segment
    2. Hospital*
      1. Introduction
      2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
    3. Clinic
    4. Pharmacies and Drug Stores
  9. Global Allogeneic Stem Cells Market – By Region

    1. Introduction
      1. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
      2. Market Attractiveness Index, By Region
    2. North America
      1. Introduction
      2. Key Region-Specific Dynamics
      3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
      4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
      5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
        1. U.S.
        2. Canada
        3. Mexico
    3. Europe
      1. Introduction
      2. Key Region-Specific Dynamics
      3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
      4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
      5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
        1. Germany
        2. U.K.
        3. France
        4. Italy
        5. Spain
        6. Rest of Europe
    4. South America
      1. Introduction
      2. Key Region-Specific Dynamics
      3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
      4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
      5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
        1. Brazil
        2. Argentina
        3. Rest of South America
    5. Asia Pacific
      1. Introduction
      2. Key Region-Specific Dynamics
      3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
      4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
      5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
        1. China
        2. India
        3. Japan
        4. Australia
        5. Rest of Asia Pacific
    6. Middle East and Africa
      1. Introduction
      2. Key Region-Specific Dynamics
      3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
      4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
  10. Global Allogeneic Stem Cells Market – Competitive Landscape

    1. Key Developments and Strategies
    2. Company Share Analysis
    3. Product Benchmarking
    4. List of Key Companies to Watch
    5. List of Company with disruptive technology
    6. List of Start Up Companies
  11. Global Allogeneic Stem Cells Market- Company Profiles

    1. Takeda Pharmaceutical Co. Ltd.*
      1. Company Overview
      2. Product Portfolio and Description
      3. Key Highlights
      4. Financial Overview
    2. Biosolution Co. Ltd.
    3. Cynata Therapeutics Ltd.
    4. JCR Pharmaceuticals Co. Ltd.
    5. Lineage Cell Therapeutics Inc.
    6. MEDIPOST Co. Ltd.
    7. MiMedx Group Inc.
    8. Osiris Therapeutics Inc.
    9. Stempeutics Research Pvt. Ltd.(*LIST NOT EXHAUSTIVE)
  12. Global Allogeneic Stem Cells Market – DataM

    1. Appendix
    2. About Us
    3. Contact Us

List of Tables & Figures

List of Tables

Table1 Global Allogeneic Stem Cells Market Value, By Product, 2020, 2024 & 2028 ($ Million)

Table2 Global Allogeneic Stem Cells Market Value, By Application, 2020, 2024 & 2028 ($ Million)

Table3 Global Allogeneic Stem Cells Market Value, By Region, 2020, 2024 & 2028 ($ Million)

Table4 Global Allogeneic Stem Cells Market Value, By Product, 2020, 2024 & 2028 ($ Million)

Table5 Global Allogeneic Stem Cells Market Value, By Product, 2019-2028 ($ Million)

Table6 Global Allogeneic Stem Cells Market Value, By Application, 2020, 2024 & 2028 ($ Million)

Table7 Global Allogeneic Stem Cells Market Value, By Application, 2019-2028 ($ Million)

Table8 Global Allogeneic Stem Cells Market Value, By Region, 2020, 2024 & 2028 ($ Million)

Table9 Global Allogeneic Stem Cells Market Value, By Region, 2019-2028 ($ Million)

Table10 North America Allogeneic Stem Cells Market Value, By Product, 2019-2028 ($ Million)

Table11 North America Allogeneic Stem Cells Market Value, By Application, 2019-2028 ($ Million)

Table12 North America Allogeneic Stem Cells Market Value, By Country, 2019-2028 ($ Million)

Table13 South America Allogeneic Stem Cells Market Value, By Product, 2019-2028 ($ Million)

Table14 South America Allogeneic Stem Cells Market Value, By Application, 2019-2028 ($ Million)

Table15 South America Allogeneic Stem Cells Market Value, By Country, 2019-2028 ($ Million)

Table16 Europe Allogeneic Stem Cells Market Value, By Product, 2019-2028 ($ Million)

Table17 Europe Allogeneic Stem Cells Market Value, By Application, 2019-2028 ($ Million)

Table18 Europe Allogeneic Stem Cells Market Value, By Country, 2019-2028 ($ Million)

Table19 Asia-Pacific Allogeneic Stem Cells Market Value, By Product, 2019-2028 ($ Million)

Table20 Asia-Pacific Allogeneic Stem Cells Market Value, By Application, 2019-2028 ($ Million)

Table21 Asia-Pacific Allogeneic Stem Cells Market Value, By Country, 2019-2028 ($ Million)

Table22 Middle East & Africa Allogeneic Stem Cells Market Value, By Product, 2019-2028 ($ Million)

Table23 Middle East & Africa Allogeneic Stem Cells Market Value, By Application, 2019-2028 ($ Million)

Table24 JCR Pharmaceuticals Co. Ltd.: Overview

Table25 JCR Pharmaceuticals Co. Ltd.: Product Portfolio

Table26 JCR Pharmaceuticals Co. Ltd.: Key Developments

Table27 Lineage Cell Therapeutics Inc.: Overview

Table28 Lineage Cell Therapeutics Inc.: Product Portfolio

Table29 Lineage Cell Therapeutics Inc.: Key Developments

Table30 MEDIPOST Co. Ltd.: Overview

Table31 MEDIPOST Co. Ltd.: Product Portfolio

Table32 MEDIPOST Co. Ltd.: Key Developments

Table33 MiMedx Group Inc.: Overview

Table34 MiMedx Group Inc.: Product Portfolio

Table35 MiMedx Group Inc.: Key Developments

Table36 Osiris Therapeutics Inc.: Overview

Table37 Osiris Therapeutics Inc.: Product Portfolio

Table38 Osiris Therapeutics Inc.: Key Developments

Table39 Stempeutics Research Pvt. Ltd.: Overview

Table40 Stempeutics Research Pvt. Ltd.: Product Portfolio

Table41 Stempeutics Research Pvt. Ltd.: Key Developments

Table42 Takeda Pharmaceutical Co. Ltd.: Overview

Table43 Takeda Pharmaceutical Co. Ltd.: Product Portfolio

Table44 Takeda Pharmaceutical Co. Ltd.: Key Developments

List of Figures

Figure1 Global Allogeneic Stem Cells Market Share, By Product, 2020 & 2028 (%)

Figure2 Global Allogeneic Stem Cells Market Share, By Application, 2020 & 2028 (%)

Figure3 Global Allogeneic Stem Cells Market Share, By Region, 2020 & 2028 (%)

Figure4 Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure5 Global Allogeneic Stem Cells Market Y-o-Y Growth, By Product, 2020-2028 (%)

Figure6 Progesterone Oral: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure7 Progesterone Injection: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure8 Progesterone Suspended/Gel: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure9 Others: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure10 Global Allogeneic Stem Cells Market Y-o-Y Growth, By Application, 2020-2028 (%)

Figure11 Hospital: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure12 Clinic: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure13 Pharmacies and Drug Stores: Global Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure14 Global Allogeneic Stem Cells Market Y-o-Y Growth, By Region, 2020-2028 (%)

Figure15 North America Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure16 North America Allogeneic Stem Cells Market Share, By Product, 2020 & 2028 (%)

Figure17 North America Allogeneic Stem Cells Market Share, By Application, 2020 & 2028 (%)

Figure18 North America Allogeneic Stem Cells Market Share, By Country, 2020 & 2028 (%)

Figure19 South America Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure20 South America Allogeneic Stem Cells Market Share, By Product, 2020 & 2028 (%)

Figure21 South America Allogeneic Stem Cells Market Share, By Application, 2020 & 2028 (%)

Figure22 South America Allogeneic Stem Cells Market Share, By Country, 2020 & 2028 (%)

Figure23 Europe Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure24 Europe Allogeneic Stem Cells Market Share, By Product, 2020 & 2028 (%)

Figure25 Europe Allogeneic Stem Cells Market Share, By Application, 2020 & 2028 (%)

Figure26 Europe Allogeneic Stem Cells Market Share, By Country, 2020 & 2028 (%)

Figure27 Asia-Pacific Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure28 Asia-Pacific Allogeneic Stem Cells Market Share, By Product, 2020 & 2028 (%)

Figure29 Asia-Pacific Allogeneic Stem Cells Market Share, By Application, 2020 & 2028 (%)

Figure30 Asia-Pacific Allogeneic Stem Cells Market Share, By Country, 2020 & 2028 (%)

Figure31 Middle East & Africa Allogeneic Stem Cells Market Value, 2019-2028 ($ Million)

Figure32 Middle East & Africa Allogeneic Stem Cells Market Share, By Product, 2020 & 2028 (%)

Figure33 Middle East & Africa Allogeneic Stem Cells Market Share, By Application, 2020 & 2028 (%)

Figure34 JCR Pharmaceuticals Co. Ltd.: Financials

Figure35 Lineage Cell Therapeutics Inc.: Financials

Figure36 MEDIPOST Co. Ltd.: Financials

Figure37 MiMedx Group Inc.: Financials

Figure38 Osiris Therapeutics Inc.: Financials

Figure39 Stempeutics Research Pvt. Ltd.: Financials

Figure40 Takeda Pharmaceutical Co. Ltd.: Financials

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