The global glioblastoma multiforme market was valued at USD 1,245.4 million in 2019 and expected to grow at a CAGR of 7.8% to reach a market value of USD YY million by 2027.
Glioblastoma multiforme (GBM) is the malignant type of central nervous system tumor. Globally, GBM accounts for 54% of new gliomas and 45% of primary malignant tumors. GBM can be either intra tentorial (area located below tentorium cerebilli) or supra tentorial (area located above the tentorium cerebilli). New treatments are coming forward involving drugs which can be used alone or in combination with radiotherapy and chemotherapy. Still, there are more chances of reappearance when compared with electric field therapy. Increased research and clinical trials in the treatment of GBM through immunotherapy is expected to account for a significant share in the growth of the market.
The major driving forces are the increasing number of brain and other nervous system cancers, an increase in funding for companies by the closed-ended competitive companies, promising pipeline, and increasing US FDA approval of new drugs.
Rising incidence of GBM is one of the dominating factors, propelling the global GBM market. According to GLOBOCAN 2018, over 241,000 people die every year as a result of brain or nervous system cancer, where GBM is the most common form of the disease.
An increase in funding for companies by other closed-ended investment companies, for the research on GBM is also contributing to the growth of the market. For instance, in February 2018, Novocure announced that it has received capital from BioPharma Credit PLC, an investment fund of Pharmakon Advisors, LP. The term loan agreement of 150 million US dollars, will be used by Novocure to accelerate its research and development segment for improving the treatment options of GBM. However, the high expenditure involved in the research, recurrence of GBM, resistance of glioma stem cells against conventional therapies, neurotoxicity caused by commercialized drugs for GBM, along with lack of efficacy of GBM treatment leading to increase in mortality rate may restrain the growth of the market. The recurrence of GBM is expected to hamper the market growth. For instance, studies have shown that glioblastoma multiforme recurrence mostly occurs in the form of a continuous growth locally within 2-3 cm from the border of the original lesion. Also, more than 90% of patients with glioma will show recurrence at the original tumor location, and the multiple lesions will develop at a 5% rate after the treatment. Secondly, although less common, GBM may also recur through the development of new parenchymal lesions that fail to exhibit continuous growth patterns, intraventricular spread, or dissemination.
Based on the treatment type, the global glioblastoma multiforme market is segmented into drugs, electric field therapy, immunotherapy, and others.
The drug segment is expected to grow at a high rate over the period of forecast. Drugs include temozolomide, bevacizumab, carmustine, and others. Temozolomide is expected to account for significant growth in the market owing to the advantages offered by the drug, which include delayed progression without impacting the quality of life with less adverse effects of the molecule. Immunotherapy is expected to grow at a significant rate over the period of forecast. Promising immunotherapeutic drugs in the GBM pipeline is expected to grow at a considerable rate. For instance, Active immunotherapy (vaccine) involves Rindopepimut (Rintega, CDX-110), which is under development by Celldex, a vaccine that is composed of peptides.
Geographically, the global glioblastoma multiforme market is segmented into five major regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.
North America is expected to contribute to the significant market share in the glioblastoma multiforme market over the forecast period (2020-2027). This is owing to the increasing incidences of the central nervous system cancers in the geriatric population. According to the study done by the National Brain Tumor Society, in 2018, 78,980 new cases of non-malignant, primary malignant, and other central-nervous-system tumors are diagnosed in the US.
However, over the forecast period (2020-2027), the Asia-Pacific is expected to dominate the Global glioblastoma multiforme market. This is owing to the Grant of regulatory approval for new therapies for glioblastoma.
The Ministry of Health, Labour, and Welfare of Japan, in December 2017, has given permission for the Central Social Insurance Medical Council for issuing reimbursement for Novocure's Optune, a portable device used for the treatment of newly diagnosed GBM. Japan is expected to share a significant growth in the market over the forecast period. This is owing to the presence of a high number of elderly individuals as the tumor continues to grow increasing with age, peaking between 75 to 84 years of age and then declines after 85 years.
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