Listeriosis Market Size, Share, Industry, Forecast and Outlook (2024-2031)

Market Overview

The global Listeriosis market reached US$ YY billion in 2022 and is expected to reach US$ YY  billion by 2030 growing with a CAGR of YY% during the forecast period 2023-2030.

The listeriosis market trends show rising research owing to the rising technological advancements and research studies. Several antibiotics are being launched for the treatment of listeriosis. Ampicillins IV are also utilized for prevention of listeriosis in adults as well as pediatrics.

Furthermore, rising treatment for listeriosis due to the rising availability of approved antibiotics and increase in the number of listeriosis cases in the market, and an increase in the research and development is driving up the listeriosis market size.

The market is experiencing a growth in demand for drugs from North American areas as a result of the rising advancements in this field. With significant competitors like Teva Pharmaceuticals USA, Inc., Pfizer Inc., Fresenius Kabi Canada, and Aridis Pharmaceuticals Inc. actively operating in the market, the market will grow in future.

Market Scope

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Market Dynamics and Trends

Growing Research and Development by the Researchers Drive the Growth of the Listeriosis Market

One of the most dangerous infections is one that affects the central nervous system, but it is still unclear how bacteria enter the brain. the reference organism One of the deadliest illnesses of the central nervous system, neurolisteriosis, is brought on by Listeria monocytogenes (Lm), a significant foodborne pathogen. Despite being a known host associated risk factor in neurolisteriosis, immunosuppression, little is understood about the bacterial mechanisms that cause Lm's neuroinvasion.

Researchers demonstrate that the protein on bacterial surface InlB guards monocytes which are infected from Fas-mediated cell death via CD8+ T cells in a way that relies on c-Met, PI3 kinase, and FLIP, where researchers develop a clinically applicable experimental model of neurolisteriosis employing hypervirulent neuroinvasive strains injected in a humanized mouse model of infection. By extending the longevity of infected monocytes and preventing specialized anti-Lm cellular immune killing, this blockage favors the spread of Lm via infected monocytes into the brain.

The selection of InlB as a fundamental virulence gene of Lm explains for the intracellular niche that is produced by InlB-mediated cell-autonomous immune resistance, which also promotes Lm faecal shedding. We have discovered a specific process by which a bacterial infection confers an extended lifespan on the infected cells by making them immune to cell-mediated defenses. This helps Lm remain in the host longer, spread to the central nervous system, and be transmitted.

Rising Positive Outcomes from Advanced Researches Creates Opportunities for the Growth of the Market

There is no clinically approved vaccination against Listeria despite a significant mortality rate and rising drug resistance. Although investigated as anticancer vaccine vectors, attenuated Listeria strains provide protection; nonetheless, more understanding of immunodominant vector antigens would be advantageous. Researchers use mass spectrometry-based immunopeptidomics to screen for listeria peptides that are present on the outermost layer of infected human cell lines in order to find novel antigens.

Researchers find 68 Listeria immunopeptides comprising 42 distinct bacterial proteins, including numerous well-known antigens, interspersed among nearly 15,000 human self-peptides. These antigens are categorized as prospective vaccination candidates because the peptides that are frequently present on many cell lines are derived from identical bacterial surface proteins. Inducing specific CD8+ T-cell responses with these highly exposed antigens in mRNA lipid nanoparticle vaccine formulations protects mice in immunization challenge trials.

These findings highlight the potential of immunopeptidomics for the creation of next-generation bacterial vaccines and can be used to build a clinical mRNA vaccine for Listeria as well as contribute to better attenuated listeria vaccines or vectors. The market is predicted to take the lead throughout the forecast period owing to high research studies.

Side Effects Associated with the Drugs will Hamper the Growth of the Market

The drugs used for the treatment of listeriosis may have few side effects. The injection of ampicillin may have negative side effects like nausea, diarrhea, or vomiting. Rash, hives, itching, trouble breathing or swallowing, severe diarrhea (bloody or watery stools) that may happen with or without fever, stomach cramps (which may happen up to 2 months or longer after the treatment), seizures, and a recurrence of fever, sore throat, cough, chills, and other infection-related symptoms are a few side effects that can be serious.

Wheezing, trouble breathing or swallowing, swelling of the face, eyes, neck, lips, or tongue, severe diarrhea (bloody or watery stools) which can happen with or without fever, and stomach cramps (which may occur up to 2 months or more after your treatment) are all possible adverse effects of amoxicillin. These side effects may restrain the growth of market.

Market Segment Analysis

The global listeriosis market is segmented based on type, drugs, route of administration, distribution channel and region.

Owing to High Prevalence, the Invasive Listeriosis from Type Segment Accounted for Approximately 65.3% of the Listeriosis Market Share

The invasive listeriosis category from type held the largest market share in 2022 and is expected to maintain its dominance over the forecast period due to a growth in incidence of listeriosis worldwide. A more serious form of the illness, invasive listeriosis, strikes some high-risk populations. These persons include those who are expecting, those receiving treatment for cancer, HIV, or organ transplants, elderly people, and children.

The symptoms of this type of sickness are severe, and the death rate is significant (20–30%). Fever, septicemia, myalgia (muscle pain), and meningitis are among the symptoms. The incubation phase typically lasts one to two weeks, but it can sometimes be as long as 90 days. For the diagnosis of listeriosis in humans, several detection techniques are available, especially polymerase chain reaction (PCR).

Blood or placenta cultures have been the most reliable tests to determine if symptoms are caused by listeriosis during pregnancy. About 20 times as many pregnant women have listeriosis as other healthy individuals do. It may lead to stillbirth or miscarriage. Low birth weight, septicemia, and meningitis can also affect newborns. A person with HIV has a minimum 300-fold higher risk of contracting an illness than someone with a healthy immune system.

Source: DataM Intelligence Analysis (2023)

Geographical Penetration Share

North America Accounted for Approximately 37.2% of the Market Share in 2022, Owing to the Strong Presence of Major Players and Increasing Healthcare Infrastructure Investment

Due to the rising need for listeriosis treatment in healthcare, manufacturers in North America have chances of increasing their operations. There are many producers and suppliers in North America and owing to the quick economic growth of the region, industrial production has expanded, driving the demand for drugs for listeriosis.

Increasing expenditure on healthcare and rising research studies, advancement of technologies for treatment of infectious disease, and increase in pharmaceutical and biotechnology business establishment across the region are also contributing to the growth of listeriosis market share of this region.

It is also anticipated that the main healthcare organizations' and enterprises' collaborative research projects as well as new product development, which constantly seeks to improve available alternatives, will contribute to the expanding demand. Individuals are becoming more aware of various drugs such as ampicillins for intravenous usage for management purposes, leading to the expansion of the market in this region. The above-mentioned factors further proves the dominance of North America on a global scale.

Source: DataM Intelligence Analysis (2023)

Competitive Landscape

The major global players in the listeriosis market include Teva Pharmaceuticals USA, Inc., Pfizer Inc., Fresenius Kabi Canada, Intelicure Lifesciences, Reticine Pharmaids, Aridis Pharmaceuticals Inc., Aden Healthcare, USAntibiotics, Cepham Life Sciences and Anant Pharmaceuticals Pvt. Ltd. among others.

COVID-19 Impact Analysis

Russia Ukraine Conflict Analysis

Due to the low prevalence as well as absence of major market participants in this region, it is predicted that the Russia-Ukraine conflict will not have a significant effect on the worldwide listeriosis market. The growth of the global listeriosis market, however, is anticipated to be relatively unaffected by the import and export of raw materials over the forecast period.

Key Developments

• On August 11, 2023, in conjunction with regional and local partners, Centers for Disease Control and Prevention (CDC)  and the U.S. Food and Drug Administration (FDA) are looking into a listeria monocytogenes infection outbreak that may be related to Real Kosher Ice Cream of Brooklyn, New York's Soft Serve On The Go ice cream cups.
• On May 12, 2022, following the treatment of Listeria monocytogenes-infected cells with ampicillin, researchers noticed intracellular production of antibiotic-resistant Listeria monocytogenes L-forms. The findings reported here give compelling evidence that antibiotic administration to infected host cells can cause intracellular Listeria monocytogenes to produce L-forms. Furthermore, these findings imply that intracellular L-forms remain inside host cells indicating that they represent live, still-growing, proliferating bacteria.

DMI Opinion:

The global listeriosis market is going to see moderate growth in upcoming years owing to rising usage of antibiotics for listeriosis. Several researches are taking place worldwide for intravenous ampicillin development. Numerous advances are taking place leading to the growth of market such as novel antibiotics. According to DMI the listeriosis market will see a decent growth with several novel therapies in the market.

Why Purchase the Report?

• To visualize the global listeriosis market segmentation based on type, drugs, route of administration, distribution channel and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development.
• Excel data sheet with numerous data points of listeriosis market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.

The global listeriosis market report would provide approximately 53 tables, 54 figures and 195 Pages.

Target Audience 2023

• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies