Gastroesophageal Reflux Disease Therapeutics Market Size, Competitive Landscape and Market Forecast - 2029

SKU: DMPH5060 | Last Updated On: May 24 2022 | Available Formats

> Global Gastroesophageal Reflux Disease Therapeutics Market Expected to reach a high CAGR By 2029: DataM Intelligence.

Gastroesophageal Reflux Disease Therapeutics Market is Segmented By Type (Mild, Moderate, Severe), By Drug Class (Antacids, Proton Pump Inhibitors, Histamine blockers, Pro-Kinetic Agents, Others), By Distribution Channel (Hospital Pharmacy, Retail Pharmacy, Online Pharmacy, Others), By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2022-2029


Market - Overview

The global gastroesophageal reflux disease therapeutics market size was valued US$ XX million in 2021 and is estimated to reach US$ XX million by 2029, growing at a CAGR of XX % during the forecast period (2022-2029).

GERD is a digestive disorder that occurs when stomach contents such as acid, food, and fluids reflux into the esophagus. It irritates the esophageal lining, resulting in patients experiencing a burning sensation. Heartburn (reflux) and regurgitation are two of GERD's most common esophageal symptoms. In most cases, GERD symptoms can ease through diet and lifestyle changes. But some people may need medication or surgery.

Source: DataM Intelligence Analysis (2021)

Market Dynamics

The latest treatment for Gastroesophageal Reflux Disease is expected to drive market growth.

TIF (transoral incisionless fundoplication) is a procedure for treating GERD. Compared to laparoscopic surgery, TIF can result in quicker treatment duration, less pain, and a speedier recovery. A specific TIF device is used to make a path for an endoscope, a flexible, tube-like imaging instrument. The treatment allows the doctor to repair or replace the valve that acts as a natural barrier to reflux using preloaded tweezers and fasteners. Currently, clinical trials are being conducted to determine the efficacy of endoscopic therapy for GERD. An endoscopic sewing machine is used to insert stitches in the stomach, increasing the anti-reflux barrier. Thus, the market is expected to drive in the forecast period from the above statements.


Side effects associated with the drugs is expected to hamper the market growth.

Industry Analysis

Porter’s Five Forces:

Source: DataM Intelligence Analysis (2021)

Supply Chain Analysis:

COVID-19 Impact Analysis

The COVID-19 pandemic has moderately impacted healthcare systems and the market. Barrett's esophagus (BE) and gastroesophageal reflux disease (GERD) may be new comorbidities linked to COVID-19. BE, a disease in which GERD destroys the esophagus squamous mucosa, affects 5.6 percent of individuals in the United States. ACE2 is significantly expressed in the esophagus of BE patients, and the acid pH associated with the disease is a crucial inducer of ACE2 expression. When human primary monocytes are infected with SARS-CoV-2, they express more ACE2 and have a larger viral load when grown at a lower pH.

Moreover, it also discovered that individuals on proton pump inhibitors, commonly prescribed for GERD, have a higher chance of developing severe COVID-19, as seen by increased ICU admission and death rates. Additionally, the pandemic interrupts the supply chain. Many companies will vary to other geographic regions to ensure that products remain available and protect their supply chain. Thus, from the above statements, the market got affected, and it is expected to gain traction quickly with the resumption of the economic activities.

Segment Analysis

Proton Pump Inhibitors segment is expected to hold the largest market share in gastroesophageal reflux disease therapeutics market

The proton pump inhibitors segment is expected to dominate in 2021. Proton pump inhibitors (PPIs) are the most widely used heartburn medication. They are the strongest available option for stopping acid production and are very convenient because they're so commonly used. Moreover, they are reported to effectively prevent the recurrence of reflux symptoms and esophageal erosions/ulcers. For instance, Esomeprazole (Nexium) is the prescription drug used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which the backward flow of acid from the stomach causes heartburn and possible injury to the esophagus (the tube between the throat and stomach) in adults and children 1 year of age and older. Therefore, it has increased the demand for drugs to treat gastroesophageal reflux disease. Thus, the market segment is expected to hold the largest market share in the forecast period from the above statements.

Source: DataM Intelligence Analysis (2021)

Geographical Analysis

North America region holds the largest market share in the global gastroesophageal reflux disease therapeutics market

In 2021, North America accounted for the highest revenue share. Rising geriatric population, increasing prevalence of obesity cases, well-established infrastructure, increasing adoption of drugs for the gastroesophageal reflux disease and increasing clinical trials in the region are some factors the market is expected to boost in the forecast period. For instance, according to the Centers for Disease Control and Prevention, All U.S. states and territories have an obesity rate of at least 20%. Overall, adult obesity rates are higher for women. The percentage of obese children is rising, with 39 million overweight and obese children under age five in 2020. Moreover, the U.S. spends almost $150 billion per year on obesity-related medical costs, and early one in four young adults is too heavy to serve in the U.S. military.

Additionally, Ironwood Pharmaceuticals, Inc. conducted clinical trials in 2021 to evaluate the safety and efficacy of IW-3718 administered to patients with GERD. Therefore, it has increased the demand for gastroesophageal reflux drugs. Thus, the North American region is expected to hold the largest market share in the forecast period from the above statements.

Source: DataM Intelligence Analysis (2021)

Competitive Landscape

Major key players in the gastroesophageal reflux disease therapeutics market Merck Sharp & Dohme Pty Ltd., McNeil Consumer Pharmaceuticals Co., Amneal Pharmaceuticals LLC, AstraZeneca Pharmaceuticals LP, Teva Pharmaceuticals USA, Inc., Takeda Pharmaceuticals America, Inc., Eisai R&D Management Co., Ltd, TWi Pharmaceuticals USA, Inc., Lannett    and Saol Therapeutics Inc. 

AstraZeneca Pharmaceuticals LP:


AstraZeneca Plc (AstraZeneca) is a biopharmaceutical company, which discovers, produces and commercializes a wide range of prescription drugs. It focuses on therapy areas such as respiratory, cardiovascular, renal and metabolic diseases; and cancer, besides autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. It operates in over 100 countries, and its innovative medicines are used by millions of patients worldwide.

­Product Portfolio:

NEXIUM (esomeprazole magnesium): It is a proton pump inhibitor indicated for treating gastroesophageal reflux disease (GERD) and risk reduction of NSAID-associated gastric ulcers.

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  • Visualize the composition of the gastroesophageal reflux disease therapeutics market segmentation by type, drug class, distribution channel and region highlighting the key commercial assets and players.
  • Identify commercial opportunities in gastroesophageal reflux disease therapeutics market by analyzing trends and co-development deals.
  • Excel data sheet with thousands of data points of gastroesophageal reflux disease therapeutics market- level 4/5 segmentation.
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The global gastroesophageal reflux disease therapeutics market report would provide an access to an approx. 45+market data table, 40+figures and 160pages.

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