The high-performance liquid chromatography (HPLC) Market . The size was valued at US$ XX billion in 2022 and is estimated to reach US$ XX billion by 2029, growing at a CAGR of XX % during the forecast period (2022-2029).
High-Performance Liquid Chromatography (HPLC) is a form of column chromatography that pumps a sample mixture or analyte in a solvent (known as the mobile phase) at high pressure through a column with chromatographic packing material (stationary phase).
Source: DataM Intelligence Analysis (2020)
The rising adoption of the HPLC technique will drive the high-performance liquid chromatography (HPLC) Market in the forecast period. The rising importance of HPLC tests in drug approvals is expected to drive the growth of the High-performance Liquid Chromatography (HPLC) Market
The rising adoption of the HPLC technique will drive the high-performance liquid chromatography (HPLC) Market in the forecast period
HPLC plays a critical role in pharmaceutical industries and analysis. It is used to test the products and detect the raw ingredients used to make them, i.e., qualitative and quantitative analysis. Moreover, the importance of HPLC uses in these fields falls under the stringent regulations established by the U.S. Food and Drug Administration (FDA).
HPLC is generally used in the pharmaceutical industry, as it can provide the precise results required. The results can analyze finished drug products and their ingredients quantitatively and qualitatively during the manufacturing process. An HPLC Lab tests food for pesticides and other chemicals. Generally, high-performance liquid chromatography (HPLC) is described as a chromatographic technique used to separate a mixture of compounds in the fields of analytical chemistry, biochemistry, and industry. The main purposes of using HPLC are to identify, quantify, and purify the mixture's components. As it relates to the food industry, HPLC instrumentation is used to detect the chemical compounds often involved in agriculture.
Recently, UHPLC has been developed to improve on L.C. methods. Forensic science is being used in combination with tandem mass spectrometry to improve the accuracy and resolution of the technique.
The rising importance of HPLC tests in drug approvals is expected to drive the Market
HPLC is the most utilized diagnostic device as a part of medication investigation. Presence of impurities in pharmaceutical drugs can pose a threat to the safety of patients, may cause negative reactions in patients and they may compromise the effectiveness of the drug's API. Due to these reasons, testing for impurities is essential in pharmaceutical quality control, and it's a step in which HPLC plays a major role.HPLC helps to separate the constituent parts of a mixture, such as a drug, allowing analysts to verify what those parts are. As a result, pharmaceutical companies use HPLC to determine if a drug contains substances that should not be there. With this data, drug manufacturers can find ways to remove the impurities so that the drugs that will eventually be given to patients perform as intended.
In 2020, CDER approved 53 novel drugs, either as new molecular entities (NMEs) under New Drug Applications (NDAs) or as new therapeutic biologics under Biologics License Applications (BLAs).
High-cost of HPLC will hamper the Market
HPLC can be costly and requires large quantities of expensive organics. Techniques such as solid-phase extraction and capillary electrophoresis can be cheaper and even quicker, especially for analysis under good manufacturing practice. Although it is relatively easy to use existing HPLC methods, it can be complex to troubleshoot problems or develop new methods. This is large because of the array of different modules, columns and mobile phases. Typical laboratory separation techniques involve developing an assay or separation method and then implementing that assay to separate individual compounds from a solution. However, this usually results in multiple solutions that also need to undergo procedures, leading to an exponential increase in complexity. Although HPLC can often simplify and speed up this process, the cost of developing an HPLC apparatus can become tremendous. Developing an HPLC apparatus, although much more efficient, is much more costly than developing other assays for separating compounds. This makes it not financially viable for many small privately-owned laboratories.
Market Industry Analysis
Porter's Five Forces Analysis:
COVID-19 Impact Analysis
During COVID-19 high-performance liquid chromatography (HPLC) Market has witnessed growth due to its use in approval, detection and validation of drugs. In a study published online in June 2020, liquid chromatography coupled along with mass spectrometry was used to quantify remdesivir in the blood plasma of a COVID-19 patient and thus provide data on its efficacy as a treatment for SARS-CoV-2. According to some studies, two analytical methods were developed and validated to determine favipiravir using fluorescence spectroscopy and solvent-free HPLC.
High-performance Liquid Chromatography (HPLC) Market Segment Analysis
The instrument segment has dominated the Market
HPLC instrument generally consists of a degasser, sampler, pumps, and a detector. The sampler brings the sample mixture into the mobile phase stream, and is carried into the column. Implementation of HPLC requires the use of analytical instrumentation. There are two main reasons for this: The first reason is that sophisticated instruments are needed to create suitable conditions for the method . The second reason is that reproducible control of these conditions is critical. An HPLC system at first appears daunting to the new operator and on full understanding of the components common to all HPLCs can transform bewilderment regarding a complicated arrangement of tubing and electronics into an appreciation of a logical and well-designed piece of analytical equipment.
Shimadzu ELSD-LT III a new compact evaporative light scattering detector for universal detection of non-volatile and semi-volatile analytes for HPLC or UHPLC applications.
The clinical research segment will dominate the Market in the forecast period
High-performance liquid chromatography or HPLC has played a significant role in clinical laboratories and research for separating and quantitating biomarkers in different body fluids. Advancement in column packing materials technology such as sub-micron superficially porous silica particles introduced the ultra-high pressure HPLC, which improved separation efficiencies without encountering high backpressures. The introduction of micro-bore columns offers faster analysis . A combination of other advances such as efficient autosamplers, reduced detector cell volumes, data collection and analysis improvements contribute significantly to high sample throughputs in clinical laboratories. This is a key requirement in the laboratories that need to generate reports on hundreds of samples for multiple parameters daily. It is used for the testing of organic compounds. Clinical research involves evaluation studies of developed drugs.
Researchers at Virginia Commonwealth University used microdialysis and HPLC to assess the concentration of various amino acids in head injury patients admitted to the intensive care unit.
Source: DataM Intelligence Analysis (2020)
North America is expected to dominate the Market in the forecast period
North America region dominates the high-performance liquid chromatography (HPLC) Market due to its increased funding for clinical R&D, a growing number of pre-clinical activities by pharmaceutical companies and flourishing pharmaceutical companies in this region. The U.S. pharmaceutical industry is a highly globalized industry with a huge positive influence on global health, prosperity, and economic productivity. Individually it holds over 45 percent of the global pharmaceutical Market , and it can be said to be the most important.
The contribution of the U.S. pharmaceutical industry is so massive that five of the world's top ten (10) pharmaceutical companies are headquartered in the U.S. These companies are all multinationals but run their operations around the globe from the U.S.
These top 5 companies include Johnson & Johnson, Pfizer, Merck & Co., AbbVie and Abbott Laboratories. According to their 2019 revenue, 15 of the 30 top Pharmaceutical companies of 2019 are headquartered in the U.S.
High-performance Liquid Chromatography (HPLC) Market Competitive Landscape
The high-performance liquid chromatography (HPLC) Market has both local as well as global companies. Some prominent key players in this Market are Shimadzu Corporation, Agilent Technologies, Phenomenex, Thermo Fisher Scientific, Waters Corporation, Jasco, PerkinElmer, Novasep, Bio-Rad Laboratories, Gilson, Wincom company ltd, Good Science (Tianjin) Instrument Technology Co., Ltd. and Zhejiang Fuli Analytical Instrument Co., Ltd
High-performance Liquid Chromatography (HPLC) Market Key Companies to Watch
Thermo Fisher Scientific
Overview: Thermo Fisher Scientific Inc. is the world leader in serving science, with approximately 70,000 employees globally. It is an American provisioner of scientific instrumentation, reagents and consumables, software and services to healthcare, life science, and other laboratories in academia, government, and industry (including biotechnology and pharmaceutical sectors). They help all their customers to accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to Market and increase laboratory productivity. Their premier brands Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services offer an unmatched combination of innovative technologies, purchasing convenience, and comprehensive services.
Product Portfolio: The Company offers scientific instrumentation, reagents and consumables, and software and services to healthcare, life science, and other laboratories in academia, government, and industry (including in the biotechnology and pharmaceutical sectors)
Key Development: On June 16th, 2021, Thermo Fisher announced Thermo Scientific™ SampleManager™ LIMS, SDMS and LES Software version 12.2 Service Pack 3.
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