The global splenomegaly therapeutics market is growing at a high CAGR during the forecast period (2022-2029).
Splenomegaly is a condition in which the spleen grows in size or weight. Hematopoiesis and immunosurveillance are important functions of the spleen. The spleen's main functions include the removal of abnormal erythrocytes, the removal of microorganisms and antigens, and the synthesis of immunoglobulin G. (IgG).
The factors influencing the global splenomegaly therapeutics market are the increasing research and development and the growing prevalence of splenomegaly.
The increasing research and development is expected to drive the market growth in the forecast period
Splenomegaly is a condition in which the spleen grows in size or weight. Hematopoiesis and immunosurveillance are important functions of the spleen. The spleen's main functions include the removal of microorganisms and antigens and the clearance of senescent and abnormal erythrocytes and their remnants, opsonized platelets, and white blood cells. The spleen also functions as a secondary lymphoid organ, maturing and storing T and B lymphocytes, and is involved in the production of immunoglobulin G (IgG) by mature B-lymphocytes in response to interactions with T-lymphocytes. The immune system peptides properdin and tuftsin are also made in the spleen. The spleen stores about one-third of all circulating platelets. The spleen is normally found within the peritoneal cavity in the left upper quadrant, between ribs 9 and 12. The normal-sized spleen surrounds the stomach, colon, and left kidney.
Moreover, splenomegaly treatment aims to treat the underlying disease while protecting the patient from splenomegaly-related complications. Patients with splenomegaly from any cause are more likely to have their spleen rupture, so extra care must be taken to protect them from abdominal trauma. Treatment options range from avoiding abdominal injury in a young, healthy patient with splenomegaly due to infectious mononucleosis to splenectomy in a patient with hairy cell leukemia who has a massively enlarged spleen. Similarly, the prognosis is heavily influenced by the underlying disease.
Limitations associated with splenomegaly treatment are expected to hamper the market growth
There are many limitations associated with the splenomegaly treatment. For instance, limit contact sports and other activities that could rupture the spleen. A ruptured spleen can result in significant blood loss and even death. It's critical to find out what's causing the spleen to enlarge. An enlarged spleen can cause serious complications if left untreated. Treatment of the underlying cause of the enlarged spleen can usually prevent the spleen from being removed. The spleen may need to be surgically removed in some cases (splenectomy). The spleen will most likely be removed via laparoscopy rather than open surgery if surgery is required. This means that the surgery is done through a series of small incisions. The surgeon uses a laparoscope to view and remove the spleen. To avoid infection, vaccines or other medications are required.
The spleen plays a critical role in immune system modulation, regulating T and B cell responses to antigenic targets in the blood, and coronaviruses have been shown to prefer the spleen. In COVID-19 patients, the splenic immune function appears to be impaired, resulting in a higher mortality rate and superimposed infections. Further research could lead to a better diagnostic and therapeutic approach for SARS-CoV-2 infected patients, particularly those with pre-existing liver and spleen diseases, who appear to have a higher risk of a negative outcome. Hence, the market is expected to be positively impacted by increasing demand for impaired splenic immune function treatment.
The Antibiotic Therapy segment is expected to dominate the market growth
Splenomegaly is a condition in which the spleen grows in size. The condition is also known as spleen enlargement or enlarged spleen. The lymphatic system includes the spleen. It aids the immune system by storing white blood cells and assisting in antibody production. The doctor will need to address the underlying cause of the enlarged spleen. If an infection is the cause of an enlarged spleen, the doctor may prescribe antibiotics depending on the organism that caused the infection.
Antibiotic Therapy may help if a bacterial infection causes an enlarged spleen. Antibiotics would be useless if a virus caused an infection, as is the case with mononucleosis. Moreover, cefotaxime (adult dose of 2 g IV q8h; a pediatric dose of 25-50 mg/kg IV q6h) or ceftriaxone (adult dose of 2 g q12-24h; a pediatric dose of 50 mg/kg IV q12h) are two options for empiric antimicrobial agents.
North America region is expected to hold the largest market share in the global splenomegaly therapeutics market
The growing prevalence of splenomegaly and increasing research and development is expected to drive the market growth in the forecast period.
Splenomegaly is a relatively uncommon condition, with an estimated prevalence of about 2% of the US population. Infectious mononucleosis, splenic infiltration with cancer cells from a hematological malignancy, and portal hypertension are the most common causes of splenomegaly in developed countries (most commonly secondary to liver disease and sarcoidosis). Hence, the splenomegaly therapeutics market in this region is expected to boost in the forecast period.
The global splenomegaly therapeutics market is moderately competitive with mergers, acquisitions, and product launches. Some of the key players in the market are Incyte Corporation, Novartis AG, GlaxoSmithKline plc, Merck & Co., Inc., Sanofi
Overview: Incyte is a multinational pharmaceutical corporation based in Wilmington, Delaware, and Morges, Switzerland. The company was founded in 2002 when Incyte Pharmaceuticals merged with another company.
Product Portfolio: In some patients, Jakafi (ruxolitinib) has been shown to shrink the spleen and improve the core symptoms of myelofibrosis (MF), including spleen-related symptoms. Jakafi has also been shown to help patients with MF with fatigue-related symptoms.
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