The Global Bone Grafts And Substitutes Market size was worth $ 2,990.6 million in 2019 and it is estimated to grow at a CAGR of 5.2% during the forecast period 2020-2027.

Published Date: 2021-02-26


DataM forecast the Global Wound Care Market is anticipated to grow at a CAGR of 5.2% from 2020 to 2027

Bone grafts are implantable materials that promote bone healing, bone formation, and osseous reconstruction due to osteoconductive, osteogenic, and osteoinductive properties. 

Bone grafting is a surgical procedure for replacing a missing or defective bone with materials (bone graft) from a patient’s body, cadavers, animals, or a different person. 

Bone grafts can also be used to fill voids in case of the absence of bones or to provide structural stability. The cell-based matrices segment is estimated to grow over the forecast period. They offer better reproducibility and cost-effectiveness compared to the other product types available in the market.

The rapid development of novel bone graft materials such as biocompatible synthetic bone grafts and the rise in bone and joint disorders are the major factors driving the growth of the global bone grafts and substitutes market. Moreover, a surge in the number of patients with rheumatoid arthritis, osteoarthritis, and other joint disorders has supplemented the market growth. However, the high cost of surgeries and several ethical issues associated with bone grafting procedures have hampered the market development. On the contrary, the increasing inclination of key market players toward R&D activities and surge in demand for orthopedic procedures among geriatric populations would provide lucrative opportunities for the market leaders in the coming years. The United States accounts for a major share in the market studied, owing to the increasing incidences of sports injuries, joint disorders, rapid adoption of advanced technology, and improved healthcare system, along with the reimbursement scenario. According to the US Arthritis Foundation, arthritis is the leading cause of disability among adults. By conservative estimates, about 54 million adults have been diagnosed with arthritis, and almost 300,000 children have had arthritis or a rheumatic condition.

Thus, considering the rising incidences of joint disorders and increasing technological advancements, the US bone grafts and substitutes market is expected to grow rapidly over the forecast period. The market studied is moderate to highly competitive, and several local and international companies are present in the market. There is a rising technological development in the field of bone grafts and substitutes. For instance, in January 2019, one of the market players, Bioventus, announced the launch of OSTEOMATRIX+, its next-generation biphasic bone graft for bone remodeling in a variety of orthopedic and spine applications.

Market Dynamics


  • Rising Incidence of Bone and Joint Disorder
  • Advancements in bone grafts & substitutes
  • Increasing demand for dental bone grafts


  • High costs of surgeries
  • Increased scrutiny of stem cell-derived products

Increasing Incidence Of Bone And Joint Disorder

Growing demand for MIS, biologics, and instrumentation have led to more reliable spinal fusion and has reduced patient morbidity. Degeneration of bones and joints brought about by aging leads to instability and stenosis. This has increased the demand for spinal fusion and joint reconstruction. Spinal fusion and repair help in disc herniation, traumatic spinal injuries, congenital and degenerative spinal conditions, and tumor removal. Additionally, the baby boomer population's desire to remain active is leading them to opt for spinal fusion and joint reconstruction procedures. Advancements in surgical technology have reduced the pain that a patient may experience during surgery. Computer navigation allows surgeons to put instrumentation such as pedicle screws into the spine with minimal invasion using three-dimensional visualization, making the procedure safer and faster. Various bone and joint disorders affect the body's musculoskeletal system, including arthritis, osteoarthritis, rheumatoid arthritis, osteoporosis, and fractures. Arthritis is the leading cause of disability among adults in the United States. Almost 50 million people in the United States experience arthritis.

According to the data from the World Population Prospects: The 2017 Revision, the number of older people (those aged 60 years or above) is expected to more than double by 2050, rising from 962 million in 2017 to 2.1 billion in 2050 and 3.1 billion in 2100. 

Globally, the population aged 60 years or above is registering faster growth than all younger age groups. The aging populace is more prone to musculoskeletal disorders, such as arthritis and osteoporosis. According to the State of Musculoskeletal Health 2019 report, in the United Kingdom, around 8.75 million people aged between 45 years and over (33%) sought treatment for osteoarthritis. The knee is the most common site in the body for osteoarthritis, followed by the hip and hands/wrists. Hence, due to the growing burden of joint disorders, there is an increasing demand for bone grafts and substitutes.

Geographical  Analysis

North America occupied the highest market share of about 35.8% in 2018, which is expected to increase to 36.8% by 2027

The North American segment of the bone grafts and substitutes market is valued at US$  1,075.4 Million in 2019 and is estimated to grow at a CAGR of 5.5% over the forecast period 2020-2027. North America holds 38.8% of the market share in 2019 and is expected to be 36.8% by 2027 for the bone grafts and substitutes market. The U.S holds 71.1% of the market share in 2019 and is expected to increase to 71.0% by 2027 for the North American bone grafts and substitutes market. The collective revenue of the bone grafts and substitutes market by North America is expected to generate USD   10,343.0 Mn from 2020-2027. North America is expected to dominate the overall market, owing to the well-established healthcare infrastructure and availability of advanced healthcare facilities. The increasing number of arthritis cases in the United States is another important factor, which is expected to increase the global bone grafts and substitutes market's growth. Technological advancement is one of the important ongoing trends in the global bone grafts and substitutes market.  The researchers and manufacturers are focusing on developing highly advanced bone grafts, which is expected to increase the growth of the overall market.  There is an enhanced availability of skilled personnel and healthcare professionals, along with the well-established healthcare infrastructure. This is expected to increase the number of orthopedic surgeries. 

Some of the market's major manufacturers have been focusing on mergers and collaborations, which can increase the growth of the overall market. 

In 2016, OsteoNovus received the U.S. FDA 510(k) clearance for NovoGro moldable bone substitute putty, a bone regeneration biomaterial developed as a bone void filler. 

Also, the key players are focusing on the development of new and advanced products, which is expected to increase the growth of the global bone grafts and substitutes market in North America. 

In 2018, Baxter International Inc., a global leader in advancing surgical innovation, announced U.S. Food and Drug Administration (FDA) clearance of Actifuse Flow Bone Graft Substitute for use in various orthopedic surgical procedures. As the newest addition to Baxter’s growing osteobiologics surgery portfolio, Actifuse Flow offers accelerated bone growth in a new, easy-to-use, pre-packaged delivery syringe for precise placement into small bony voids or gaps in the skeletal system. The increasing number of orthopedic procedures in the United States is expected to increase the global bone grafts and substitutes market. 

According to the American Academy of Orthopedic Surgeons, approximately 3 million musculoskeletal interventions operate annually in the United States. Moreover, bone grafts are also reported to be used worldwide in approximately 2.2 million orthopedic procedures.

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