Major factor influences the Veterinary Pain Management Market

The increasing government initiative towards animal healthcare is driving the global animal pain management market.

In November 2019, the Global Pain Council (GPC) of the World Small Animal Veterinary Association (WSAVA) has launched a program called ‘Teach the Teachers,’ which aims to create a global network of key opinion leaders (KOLs) – ‘teachers’ – in pain management, who are motivated to propagate and disseminate their knowledge within their regions.

In March 2020, Ceva Animal Health, the manufacturer of Ketofen® 10%, launched a ‘Wave Goodbye to Pain’ campaign to highlight the positive impact of pain relief on lame cattle and its role in improving recovery time and results. The initiative was launched following a study by Nottingham University, which revealed that NSAIDs (anti-inflammatory and pain-relieving injections) have a synergistic (greater than simply additive) effect when given alongside effective hoof trimming and blocking to treat lameness.  The findings have emerged alongside a second study showing that over the last 10 years, farmers are increasingly aware of the need for pain relief, and 52% are happy to pay the extra costs involved (up from 36% in 2006).

An increasing number of companion animal ownership is boosting the market growth for the veterinary pain management drugs market. Developing economics and increasing disposable income are prime causes for increased pet ownership within the South American region. Further, the continued strengthening of the bond between owners and their animal companions is also helping the market to achieve a sustainable growth rate for the next few years. Growing companion animal care expectations and demand also play an important role in the companion animal healthcare market's development and growth. Moreover, the rising life expectancy of companion animals such as cats and dogs is also boosting the market's growth. Developing countries are also experiencing increased pet ownership & expenditure, which would further fuel the market growth with the region. Increased disposable income, the greater life expectancy of animals, increased pet ownership, and increased need for animal healthcare would propel the veterinary healthcare market towards viable growth.

SIDE-EFFECTS OF DRUGS

Some of the most common side effects of NSAIDs in animals reported to the FDA’s Center for veterinary medicine are vomiting, decreased to no appetite, decreased activity level, and diarrhea.

NSAIDs are associated with gastrointestinal ulcers/perforations, kidney and liver toxicity and must be used cautiously in animals with pre-existing kidney or liver problems.

The Digestive Tract (Stomach and Intestines):

Nonsteroidal anti-inflammatory drugs can cause side effects in the digestive tract both directly and indirectly. The direct effects are related to the drugs’ physical properties. Many NSAIDs become trapped in the stomach and are slightly acidic, directly irritating the stomach lining. The indirect effects are NSAIDs either preventing the body from making prostaglandins or blocking the protective activity of these substances. Remember, besides contributing to pain, inflammation, and fever, prostaglandins also protect the stomach and intestines' lining. When fewer prostaglandins are produced, or some of their activity is blocked, the entire digestive tract may be more prone to damage. This can lead to ulcers and perforations (holes) in the stomach and intestines. Giving an animal two NSAIDs simultaneously or an NSAID with a steroid such as prednisone increases the risk of side effects in the digestive tract and should be avoided.

Kidneys:

During periods of decreased blood flow to the kidneys—such as when an animal is dehydrated, under anesthesia, or has kidney disease—prostaglandins cause the arteries going to the kidneys to open. This helps keep blood flowing to these vital organs. Because NSAIDs prevent prostaglandins production or block some prostaglandin activity, these drugs can reduce blood flow to the kidneys, possibly causing kidney damage and leading to sudden-onset kidney failure. NSAIDs should be used cautiously in animals that may already have kidney disease or other conditions that cause reduced blood flow to the kidneys, like dehydration and shock. If an NSAID is used around the time of surgery, intravenous (IV) fluids are generally recommended before, during, and after anesthesia to maintain blood flow to the kidneys, hopefully reducing potential kidney complications.

Liver:

NSAIDs' side effects on the liver can be divided into two categories: (1) dose-dependent toxicity; and (2) dose-independent toxicity.

As the name implies, dose-dependent liver toxicity is related to the dose—the higher the dose of the NSAID, the worse the liver damage. Dose-dependent liver toxicity is typically caused by a massive NSAID overdose, such as a dog eating an entire bottle of his owner’s ibuprofen. (The ASPCA Animal Poison Control CenterExternal Link Disclaimer receives hundreds of calls each year involving dogs and cats that accidentally eat nonsteroidal anti-inflammatory drugs.) Dose-independent liver toxicity can occur at any dose, even the correct one, and is an unpredictable reaction where the patient’s liver has an abnormal sensitivity to the NSAID. Most NSAID-associated liver damage occurs within the first three weeks of starting the medication.

NSAIDs should be used cautiously in animals that may already have liver disease.

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